WHAT IS XENICAL ®?

Xenical is the commercial mark of the product Orlistat, which it is possible to acquire in the drugstores at present. It takes for mouth in the shape of capsules, and is indicated in certain types of obesity, under medical control.

PERFORMANCE

Xenical operates blocking an enzyme (lipasa pancreatic) that is in the intestines. It is enzyme breaks the greasy acids so that they could be absorbed from the intestine towards the blood. The Xenical blocks this enzyme and makes to spend a third of the fats for the intestine towards the dregs, without they c be absorbed.

EFFICACY

Clinically it has been demonstrated that a balanced diet more Xenical is the double of effective that the diet only in the control of the weight. It goes so far as to reduce 30 % of the absorption of the fats. The loss of weight, in the clinical studies, has come to 20 % and of the corporal fat in 16 %. This loss is supported in 50 % the year before having suspended the treatment.
It does not act like other medicines altering the metabolism and for it it does not produce effects in the central nervous system. The Xenical has been approved by the European Union for his commercialization, which is realized from the summer 1999.

SIDE EFFECTS

• Stomach inconveniences.
• Diarrhea, her part for the increase of the fats in the dregs; for it it must consume less fats. It is necessary to take a vitamínico complex as a supplement, since any vitamins liposolubles cannot to be absorbed.
• Cases of breast cancer have appeared more often than the habitual thing in women taking Xenical. It is not conclusive information.

• It diminishes the cholesterol and the LDL (lipoproteínas of low thickness), but it alters neither the triglicéridos nor the HDL (lipoproteínas of high thickness).

• In the magazine Lancet (1998 July 18; 352 (9123):167-72) an European multicentral study appears with Orlistat, in 743 patients with 120 mg of medicine for 1 year. Earlier they were only with a hypocaloric diet (600 kcal of deficit), and later another year with diet and together Orlistat. The patients with Orlistat lowered his levels of Cholesterol and of LDL cholesterol, the glucose in blood and the insulin. It appeared 10 % of grown thin in the agreements with the medicine in one year, and on having suspended it, they were late more in recover the weight that not agreements.

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