In this group there are the new medicines that have been approved for his use in the erectile malfunction, obtaining and supporting an erection peneana sufficient to realize a satisfactory sexual act.

SILDENAFIL (VIAGRA ®)

It is the first medicine that left to the market in his group of performance for the erectile malfunction. In the realized studies, sildenafil it improved the erections in 3 of every 4 participants (~75 %), compared with only 1 of every 4 that they improved on having taken a placebo; with sildenafil, 1 of every three attempts of coitus was a success - compared with only 1 of every 5 attempts in patients with placebo-. Viagra ® increases a substance called cyclical GMP, which takes place in the penis during the sexual activity and which increases the blood flow. This way, sildenafil there increases the flow of the penis of natural form, so that the sexual stimulation causes erection. Viagra ® is, then, neither an aphrodisiac, nor a hormone, nor a product that causes per erection, but only it helps to obtain an erection when sexual stimulation exists. Viagra ® takes "to demand" - only when it is wished - and his action begins in 30 minutes and lasts up to 4 hours. Any more than 1 tablet is not recommended a day. The collateral effects include digestive inconveniences, headaches, facial reddening and muscular pains, and, in 3 % of the agreements, alterations of the vision. As other substances to treat that OF, Viagra ® is contra-indicated in case of cardiac illnesses, and especially, one must never associate with the medicines called nitrates (for example, the nitroglycerine that is used under the language to treat the angina pectoris); in association with SILDENAFIL, the nitrates can lower the arterial tension sudden up to dangerous levels.

TADALAFILO (CIALIS ®)

It acts increasing the blood flow in the penis in the presence of sexual stimulation. His active beginning - Tadalafilo - acts like selective reversible inhibitor of the specific GMPc-fosfodiestererasa of tipo5 (PDE5). His administration must be carried out approximately 30 minutes before supporting the sexual relation. The efficacy of Tadalafilo can last up to 24 hours after the administration. Also, the food ingestion does not affect to the absorption of the Tadalafilo. The most common not desirable effects are in general of light to moderated: headache, facial reddening, rinitis, backache and muscular.

HIDROCLORURO OF APOMORFINA (UPRIMA ®)

It is an agonista dopaminérgico with affinity for the recipient D2, he acts on the brain, being able to amplify the nervous sign that increases the blood flow in the sexual organ, thanks to which the erection takes place. So that it is effective sexual stimulation is needed. His administration realizes route sublingual approximately 20 minutes before the sexual achievement. The adverse effects include the morning sickness, migraine, and sickness with faints, syncopes and syndrome vagal autolimitante. His simultaneous ingestion with alcohol can cause an increase of the incidence and scope of the low blood pressure. Uprima has the advantage of being able to be used by cardiac patients who consume nitrates, which Viagra/Levitra/Cialis could not use.

SILDENAFILO (VIAGRA ®)

It acts increasing the blood flow in the penis in the presence of sexual stimulation. His administration must be carried out approximately 60 minutes before supporting the sexual relation. Sildenafilo, at 4-5 hours of administered, was still capable of producing a reaction in answer to the stimulation. When there is administered by food the speed of absorption of sildenafilo it diminishes and the beginning of his action might be late.

VARDENAFILO (LEVITRA ®)

It acts increasing the blood flow in the penis, in the presence of sexual stimulation. His active beginning - Vardenafil - acts like selective reversible inhibitor of the specific GMPc-fosfodiestererasa of tipo5 (PDE5). His administration must realize approximately 25 to 60 minutes before the sexual relation, and his effect lasts up to 12 hours. According to an investigation with Levitra - en the one that 805 males informed - one could state that 74 % of those who took vardenafilo (active beginning of Levitra) for 12 weeks obtained an erection in the first attempt, compared with 46 % of the participants who consumed a placebo or inactive substance. The most common not desirable effects are in general of light to moderated: headache, facial reddening, morning sickness, sickness, rinitis and dyspepsia. On having administered vardenafilo with a meal with a high place contained in fats, the absorption speed diminishes, with a delay of 1 hour to reach the maximum concentration and an average reduction of the maximum plasmatic concentration of 20 %.

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