Frequent questions He asks the doctor Beginning  
LEUKEMIA CHRONIC MIELOIDE
DEFINITION SYMPTOMS DIAGNOSIS CLASSIFICATION TREATMENT OTHER TREATMENTS TO CONSULT

DEFINITION

The leukemia mieloide chronic ó leukemia granulocitica chronic is an illness in which the production of white globules increases in the bone marrow.
The bone marrow has the function to produce the cells of the blood (so much white, red like thrombocytes) for it in her there find not differentiated young cells, still, in each of these groups (leukocytes, red blood corpuscles, thrombocytes).
In the leukemia the blastos (immature cells) that they are transforming into leukocytes polimorfonucleares (granulocitos) do not mature and they are very numerous. By it they appear in the blood.

The cancerous cells of the leukemia are bearers of a chromosome that is not a normal called chromosome Philadelphia. This chromosome persists in spite of the treatment.

The leukemia mielogena chronic progresses slowly and in general happens in persons of middle or advanced age, although also it is possible to give in children.

SYMPTOMS

In the first phases of the leukemia mieloide chronic some patients do not present symptoms.
The most typical symptoms are:

  • intense weariness
  • not high fever
  • lacking in appetite
  • sudoración night
  • sensation of abdominal distension (inflamed spleen)

DIAGNOSIS

It is realized by means of a common blood test in which the leukocytes turn out to be very developing, and if this is confirmed a bone marrow biopsy is realized, to see the affectation grade.

CLASSIFICATION FOR STAGES

  • Chronic phase

In this phase, which can last months or years, few blastos are both in the blood and in the bone marrow

  • Intensive phase

They appear blastos in the blood and in the marrow with decrease of normal cells.

  • Phase blastica

At least 1/3 of the cells of the blood and marrow they are blastos, accumulations of these cells can appear in the shape of tumors at level of bones or ganglions.

Also there can be an infiltration picture meningeo, with blastos infiltration in the liquid cefaloraquídeo

  • Refractory phase

When the blastos do not diminish in spite of the treatment

TREATMENT

It is realized by three methods:

  • chemotherapy
  • radiotherapy
  • transplant of bone marrow
  • immunotherapy with stimulating or inhibiting factors of colonies of cells.

The transplant of bone marrow is realized destroying completely the marrow of the patient and then this one is replaced with another marrow, of a donor whose characteristics are similar. By it they are elected compatible relatives (very similar in the scoreboards of the cells). The complicated thing the study of the compatibility is since the skill in itself is simple and is applied straight with a needle in the marrow earlier destroyed.

TREATMENT

CHRONIC PHASE

It is realized by the following treatments:
1. Transplant of bone marrow.
2. Immunotherapy.
3. Chemotherapy to reduce the number of blastos.
4. Surgery to extract the spleen (esplenectomia).

INTENSIVE PHASE

It is realized by the following treatments:
1. Transplant of bone marrow.
2. Chemotherapy to reduce the number of white globules.
3. Transfusions of blood or blood products to relieve the symptoms.

PHASE BLASTICA

It is realized by the following treatments:
1. Chemotherapy.
2. Transplant of bone marrow.
3. Radiotherapy to relieve the symptoms caused by tumors formed in the bone.

Affectation MENINGEA

It is realized by the following treatments:
1. Chemotherapy intratecal
2. Radiotherapy to the brain.

REFRACTORY PHASE

His treatment can realize with diverse rules that all of them are in study for his evaluation.

OTHER TREATMENTS

There are new synthesis medicines in laboratory that is the inhibitor of the tirosina quinasa called Imatinib (Gleevec ®). His action is to block the tirosina quinasa, which does that the cells mother fundamental develop like white globules adult (leukocytes) in major number of the necessary ones. It is used in different stadiums of the leukemia.

IMMUNOTHERAPY

To realize the immunotherapy they are used use substances produced by the body or synthesized in the laboratory to stimulate, to direct or to restore the natural defenses of the body against the illness.

CHEMOTHERAPY WITH TRANSPLANT OF CELLS MOTHER

For it they are extracted from the bone marrow of the proper patient or of a compatible donor and freeze. After an aggressive chemotherapy they all are destroyed them extirpate cell phones blood.
With the cells frozen mothers the system will return from zero so that they produce the blood cells again. Also it is possible to do only with lymphocytes and his name is DLI.

WHAT DOCTOR CAN TREAT ME?

To look a specialist Service offered for
Writing: Medical equipment   Update: June, 2009
Know the limitations of this service


Our Feature links that help to sponsor our site
erotic , blog.moto-hobby.co.uk , used cars , nice pics , plastics , used cars ,collegamenti sponsorizzati