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 TUMOR SCOREBOARD
The tumor scoreboards are those substances that can decide for analytical methods and have a causal connection or of probability with diverse types of cancer.
They are detected by analytical methods and serve for the detection, diagnosis and prognosis of some neoplasias.
Her ß-2-microglobulina is a polipéptido identified in the patients' urine with renal tubular illness. Also there is part of the light chain of the antigens of histocompatibilidad (HLA) class I of all the nucleate cells and presents certain sequence analogy with the constant region CH-3 of the antibodies. For it, it seems to have an important immune function. Also it is synthesized in the lymphocytes and his levels séricos depend on the renewal of the cell membran.
NORMAL VALUES
The normal values are 0,8-3,0 mg/l (2,3-3,0 mg/l after 60 years). In newborn babies and children younger than one year the values are very high (up to 5,4 mg/l).
UTILITY OF THE TUMOR SCOREBOARDS
The determination of ß-2-microglobulina is used like tumor scoreboard offers big diagnostic interest in the syndromes proliferativos like mieloma multiply (even up to 90-100 mg/l), linfomas not Hodgkin, illness of Hodgkin and leukemia mieloide chronic.
A clear interrelation exists of ß-2 microglobulin with the infection for the virus of the human immunodeficiency (VIH-1 and VIH-2), being a factor predictivo independently from progression to AIDS. It is used in the drugs monitoring antirretrovirales.
Also it serves for distinguishing diagnosis of bacterial or viral infections that they affect to the central nervous system, like the encephalitis for Herpes simplex and it increases in immune and rheumatic illnesses as rheumatoid arthritis, lupus eritematoso systemic, Sjögren illness, etc...
Since he has already arranged to meet, the first clinical application was in processes that they study or collaborate with tubular renal malfunctions like dialysis, renal injury of the hypertension of the pregnancy, precocious detection of the rejection of renal transplante, poisoning with heavy metals, chronic alcoholism, medicines nefrotóxicos, uropatía obstructive and leprosy.
WHAT DOCTOR CAN TREAT ME?
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TUMOR SCOREBOARD 
