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OTHER NAMES
- ApoB100;
- Apoproteína B100.
DEFINITION
It is a blood test that serves to measure the quantity of apolipoproteína B100 (Apo B100). The utility of measurement of Apo B100 is in the context of a study of a hiperlipemia and to evaluate the factors of risk of arterioesclerosis, circulatory, coronary illnesses, etc. His elevation increases the risk of this type of illnesses.
The apolipoproteínas are a part of the complex of molecules that there transport the lípidos triglicéridos and cholesterol (HDL, LDL, VLDL). His physiological utility in the blood is to help to the transport of the lípidos and fixation to cellular recipients so that the cells have aptitude to absorb the lípidos necessary for his functioning. Apolipoproteína B100 (ApoB100) is the principal component polipeptídico of the lipoproteínas LDL, and almost half of the same ones of the VLDL. The ApoB100 is synthesized in the liver and there are the most important mechanism of transport of endogenous cholesterol. Apo B100 takes affinity as the recipient of the LDL placed in the cellular surface, and she is the principal causer of the deposit of cholesterol in the cells.
PROCEDURE OF SECURING
To realize this analysis it is needed to be on an empty stomach at least 6 previous hours.
- It is possible to realize the capture in an appropriate place (consultation, clinic, hospital) but sometimes it is realized in the proper domicile of the patient.
- To realize the capture it is needed of locating an appropriate vein and in general there are used the veins placed in the flexura of the elbow. The person entrusted to take the sample will use sanitary gloves, a needle (with a syringe or pipe of extraction).
- It will put a tortor (tape of gum - latex) in the arm so that the veins retain more blood and turn out to be more visible and accessible.
- It will clean the area of the prick with an antiseptic one and by means of a palpación it will locate the appropriate vein and will gain access to her with the needle. They will release the tortor.
- When the blood flows for the needle the sanitary one will realize an aspiration (by means of the syringe or by means of the application of a pipe with gap).
- On having finished the capture, it extracts the needle to itself and the area is pressed with a cotton or similar torunda to favor the coagulation and it will indicate him to itself that flexione the arm and the area pressed with a Band-Aid supports for some hours.
MODIFICATIONS OF THE RESULT
- The feeding rich in (animal) unsaturated fats raises the levels of Apo B100.
- The medicines that increase the level of Apo B100 are androgen, betabloqueantes, diuretics, alcohol, progesterone.
- The medicines that diminish the level of Apo B100 are the estrogen, the estatinas, the tiroxina, and the colestiramina.
PROBLEMS AND POSSIBLE RISKS
- The securing by means of a prick of the vein can produce certain pain.
- The possible difficulty in finding the appropriate vein can give place to several pricks.
- Appearance of a haematoma (bruise or cardinal) in the extraction area, is due usually to the fact that the vein has not closed well after the later pressure and blood has kept on going out producing this problem. There can apply an ointment to himself type Hirudoid or Trombocid in the area.
- Inflammation of the vein (phlebitis), sometimes the vein turns out to be shaken, well be for a cause merely physically or why it has become infected. It will have to support the relaxed area a few days and there can apply an ointment to himself type Hirudoid or Trombocid in the area. If the problem persists or appears fever will have to consult it with his doctor.
NORMAL LEVELS OF APO B100
In men from 50 to 125 mg/dl.
In women from 40 to 120 mg/dl.
EVALUATION OF THE RESULTS
The developing levels of apo B100 are related with:
- Hiperlipemia type IIa, IIb, IV and V
- Syndrome nefrótico
- Diabetes
- Hipotiroidismo
- Pregnancy
- Colestasis
- Coronary Cardiopatía isquémica
- Anorexia
The diminished levels of apo B100 are related with:
Hipertiroidismo
Malnutrition
EPOC
Rheumatic illnesses
Anemia
Slimming
TO SEE ALSO
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