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NEW ANTI-INFLAMMATORY not ESTEROIDEOS (Anti COX-2) | |
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 INFORMATION PERFORMANCE EFFECTS PRECAUTIONS EFFECTS PRODUCTS TO SEE TO CONSULT |
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The anti-inflammatory not esteroideos are a group of medicines that act blocking the prostaglandin synthesis and his effect is anti-inflammatory, analgesic (it diminishes the pain) and antipyretic (it lowers the fever).
All the medicines of this group work blocking a substance that is called Cicloxigenasa (COX), but there are at least two types of this one the COX-1 and the COX-2. The COX-1 is present especially in the intestinal textile and in the kidneys, in textile intestinal (stomach) has a protective function of the textile preventing to the formation of injuries (ulcers) or hemorrhages. This COX-1 in the kidney favors the blood contribution and improves his function. On the other hand the COX-2 is in all the textiles and cells but without an activity until for diverse causes (traumatism, infections, illnesses) the organs of the body get injured and this COX-2 enters activity producing substances that provoke inflammation and pain. The classic antinflamatorios had the property of there blocked the Cicloxigenasa (COX-1 and 2) for it his effect antinflamatorio it was coming accompanied from other effects not wished like the appearance of gastric ulcers when not hemorrhages and perforation of the stomach, renal insufficiencies with liquids retention in certain cases. The new antinflamatorios not esteroideos produce inhibition of the Cicloxigenasa 2 (COX-2) but they do not have effect on the COX-1, as it it has the beneficial effects on inflammation, pain and fever, without the proper side effects of the classic antinflmatorios (you ulcerate of stomach, renal problems).
The new antinflamatorios not esteroideos anti COX-2 do not substitute the classic antinflamatorios, must be indicated and be used when there is risk of gastric or renal problems in the patients. His administration, dosage, and indications are similar to the classic antinflamatorios, unless they cannot be taken by the patients who have illness of Crohn or ulcerous Colawsuit. They must take neither in the pregnancy nor in women who are giving of sucking his children. Since they have a metabolic effect in the liver it is necessary to have precaution in the patients who are with anticoagulant treatments and to do an analysis to fit the anticoagulant to the new situation. It is not recommended in patients of the heart or asthma, but it is not an absolute contraindication. If the allergic ones to the sulfamidas must avoid them. The following not wished effects can appear in certain cases:
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