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 DEFINITION
The PSA (Prostate-specific antigene) is a glicoproteina (serinproteasa) produced exclusively by the cells epiteliales of the prostate and in small quantities for other glands. This glicoproteina normally increases the mobility of the sperms.
In the prostate textile two specific proteins of the same one take place, one is the prostate acidic fosfatasa and other is the PSA. This protein or rather glicoproteina is the one that collaborates with the cancer of the prostate. It is not that she is increased in his formation with the cancer since the cells epiteliales of the normal textiles of the prostate and the textiles hipertróficos produce more PSA than the tumor prostate textiles.
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In the prostate cancer this protein increases his exit towards the blood stream across the glasses and lymphatic textiles that happen for the prostate.
METHODS OF ANALYSIS
Normally it is realized adding to the whey to prove an antibody monoclonal (only this glicoproteina recognizes). This antibody will be fixed only to the recognized PSA, which stay free they are eliminated by a wash. Then a radioactive scoreboard is applied or enzimático to measure the quantity of this antibody that has been fixed, what represents the quantity of PSA that exists in the tested whey.
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There are modifications of this analysis with double skills sándwich with two monoclonales, or with different scoreboards for the detection.
The elevation of the PSA-Free one indicates hiperplasia benign of prostate, if the elevation is of the PSA-Combined one it is more indicative than cancer. But the habitual measurement detects so much the free form as brought together of PSA. Specific measurements of both are developing to improve the sensibility of this analysis
The normal PSA levels depend on the age:
| AGE |
LEVELS |
| Of 40-49 years |
0.0-2.5 ng/ml |
| Of 50-59 years |
0.0-3.5 ng/ml |
| Of 60-69 years |
0.0-4.5 ng/ml |
| Of 70-79 years |
0.0-6.5 ng/ml |
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The elevation of the PSA can stem from an infection to a benign hypertrophy of prostate or to a traumatism of the same one. The most representative thing to associate the level of PSA and the prostate cancer is to observe an elevation of 0.75 ng/ml or major in 1 year.
Also it must serve to observe the evolution of the treatment of the cancer of prostate, since if the level rises after a prostatectomía it is indicative of that there persists malignant textile or a recurrence of the same one.
WHAT DOCTOR CAN TREAT ME?
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DEFINITION 
