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 DEFINITION
The antispasmodic ones belong to two different pharmacological groups: those who act for mechanism anticolinérgico and those who exercise direct action on the smooth muscle. Another difference is that the oral absorption of the quaternary compounds is more irregular than that of the tertiary aminas, for it major individual changes exist in the answer.
ANTISPASMODIC ANTICOLINÉRGICOS
They operate antagonizando the acetilcolina in the recipients muscarínicos. They usually qualify in anticolinérgicos with structure of tertiary amina and anticolinérgicos with structure of quaternary ammonium. They differ principally because the derivatives of the tertiary amina do not cross the barrier hematoencefálica and, in case of poisoning, there are less irrigations of loss of memory, psychic excitement or hallucinations.
GENERIC
Natural alkaloids and semisynthetic derivatives with structure of tertiary amina:
Derivatives of natural alkaloids with structure of quaternary ammonium:
- Butilescopolamina, bromide
- Homatropina, metilbromuro
- Metilescopolamina, bromide
- Octatropina, metilbromuro
Synthetics with structure of tertiary amina:
- Amikelina
- Trimebutina
- Dicicloverina
Synthetics with structure of quaternary ammonium:
- Clidinio, bromide
- Pinaverio, bromide
- Valetamato, bromide
ANTISPASMODIC MUSCULOTROPOS
They have direct action on the muscle as a mechanism known until now current. They must be reserved to cases where the anticolinérgicos are contra-indicated, since his efficacy is doubtful.
GENERIC II
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DEFINITION 
