Frequent questions He asks the doctor Beginning   
ANTINUCLEAR ANTIBODIES (ANN)
DENOMINATION TECHNICAL DEFINITION PROBLEMS PROVED VALUES TO SEE TO CONSULT

OTHER NAMES

  • FR.
  • RF.

DEFINITION

It is an analytical determination that measures the antibodies IgG that are specific against antigens of the nucleus of cells of the proper body.
It is used to verify the presence of the same ones in illnesses called autoimmune, as it can be systemic Lupus Eritematoso.

This test is used when suspicion is had as arthritis symptoms, exanthemas in the skin and pain or fatigue in the breast of a Systemic Lupus Eritematoso (THEY). In 95 % of the cases of THEY the result of this test is positive, although it can have turned out to be negative, and even a positive result can appear in other illnesses.

SKILL OF ACHIEVEMENT

To realize this analysis to be on an empty stomach is not needed.

There are medicines that can alter the results offering false positives as they can be: the acetazolamida, the acid aminosalicílico, the clorproxiteno, the clorotiazidas, the griseofulvina, the hidralacina, the fenilbutazona, the difenilhidantoina, the procaina, the streptomycin, the sulfamidas, and the tetraciclinas.
The asteroids, on the contrary, can negativizar the results.

It is possible to realize the capture in an appropriate place (consultation, clinic, hospital) but sometimes it is realized in the proper domicile of the patient.

To realize the capture it is needed of locating an appropriate vein and in general there are used the veins placed in the flexura of the elbow. The person entrusted to take the sample will use sanitary gloves, a needle (with a syringe or pipe of extraction).

It will put a tortor (tape of gum - latex) in the arm so that the veins retain more blood and turn out to be more visible and accessible.
It will clean the area of the prick with an antiseptic one and by means of a palpación it will locate the appropriate vein and will gain access to her with the needle. They will release the tortor.
When the blood flows for the needle the sanitary one will realize an aspiration (by means of the syringe or by means of the application of a pipe with gap).

On having finished the capture, it extracts the needle to itself and the area is pressed with a cotton or similar torunda to favor the coagulation and it will indicate him to itself that flexione the arm and the area pressed with a Band-Aid supports for some hours.

The abstracted blood moves to the analysis laboratory in a special pipe for biochemistry, which contains an anticoagulant product. In general more than 10 milliliters of blood are not usually necessary for a standard battery of biochemical parameters.

PROBLEMS AND POSSIBLE RISKS

  1. The securing by means of a prick of the vein can produce certain pain.
  2. The possible difficulty in finding the appropriate vein can give place to several pricks
  3. Appearance of a haematoma (bruise or cardinal) in the extraction area, is due usually to the fact that the vein has not closed well after the later pressure and blood has kept on going out producing this problem. Type Hirudoid can apply an ointment to itself ® or Trombocid ® in the area.
  4. Inflammation of the vein (phlebitis), sometimes the vein turns out to be shaken, well be for a cause merely physically or why it has become infected. It will have to support the relaxed area a few days and type Hirudoid can apply an ointment to itself ® or Trombocid ® in the area. If the problem persists or appears fever will have to consult it with his doctor.
NORMAL VALUES

The absence of antinuclear antibodies (ANN) ó NEGATIVE test is the NORMAL THING.
The positive results can be considered to be negative to major dilution of 1:20

Also there can give to us in the result the different bosses of coloring that are more specific than certain illnesses:

  • Homogeneous boss (THEY, mixed Illness of the collagen)
  • Outlined boss (THEY)
  • Speckled boss (THEY, Escleroderma, Rheumatoid arthritis, mixed Illness of the collagen, Syndrome of Sjogren, Polimiositis)
  • Boss nucleolar (Escleroderma, Polimiositis)

EVALUATION OF THE ABNORMAL RESULTS

The presence of antinuclear antibodies (ANN) in the blood can indicate:

  • Rheumatoid arthritis
  • Escleroderma
  • Thyroid illnesses
  • Lupus Eritematoso Sistémico (LES))
  • Mixed illness of the collagen
  • Illness of Raynaud
  • Chronic hepatitis
  • Miastenia gravis
  • Polimiositis
  • Syndrome of Sjogren

TO SEE ALSO

WHAT DOCTOR CAN TREAT ME?

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Writing: Medical equipment   Update: June, 2009
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